Gene Expression Analysis of Lipid Metabolism and Inflammation-Related Genes

EasyChair Preprint 14929

Abstract

Lipid metabolism and inflammation are tightly interconnected biological processes, with dysregulation in either pathway contributing to the pathogenesis of several chronic diseases, including cardiovascular disease, obesity, and diabetes. This study aims to investigate the gene expression profiles of lipid metabolism and inflammation-related genes to understand their molecular interplay. Key lipid metabolism genes, such as ACACA, FASN, SREBF1, and PPARs, as well as critical inflammation-related genes, including TNF-α, IL-6, NF-κB, and COX-2, were analyzed using quantitative real-time PCR (qPCR) and RNA sequencing (RNA-Seq) methods.

Samples from relevant tissues, including liver and adipose tissue, were collected and processed to examine the upregulation and downregulation patterns of these genes in various metabolic and inflammatory states. Our results show that specific alterations in lipid metabolism gene expression correlate strongly with the activation of pro-inflammatory markers, suggesting a feedback mechanism that exacerbates both metabolic and inflammatory disorders. These findings provide insight into the molecular mechanisms linking lipid metabolism and inflammation, offering potential therapeutic targets for treating metabolic diseases by modulating key genes involved in these pathways.

Keyphrases: Acetyl-CoA Carboxylasel, Inflammation, gene expression, lipid metabolism

@booklet{EasyChair:14929,
  author    = {Docas Akinyele and Godwin Olaoye},
  title     = {Gene Expression Analysis of Lipid Metabolism and Inflammation-Related Genes},
  howpublished = {EasyChair Preprint 14929},
  year      = {EasyChair, 2024}}