Inhibition of Apoptosis and Promotion of Cell Regeneration

EasyChair Preprint 14415

Abstract

Apoptosis, or programmed cell death, is a crucial cellular process that maintains homeostasis and plays a vital role in development and tissue renewal. However, dysregulation of apoptosis can lead to various pathological conditions, such as cancer, neurodegenerative diseases, and ischemic injuries. Conversely, the promotion of cell regeneration, the replacement of damaged or lost cells, is essential for tissue repair and organ function. Understanding the mechanisms underlying the inhibition of apoptosis and the stimulation of cell regeneration has significant therapeutic implications.

This review examines the key mechanisms by which apoptosis can be inhibited and cell regeneration can be promoted. Apoptosis inhibition involves the suppression of pro-apoptotic signals and the activation of anti-apoptotic pathways, such as growth factor signaling, the NF-κB pathway, and the regulation of Bcl-2 family proteins. The promotion of cell regeneration is primarily achieved through the activation and differentiation of stem cells, the stimulation of progenitor cell proliferation, and the process of dedifferentiation and transdifferentiation.

Keyphrases: Apoptosis inhibition, Stem cell-based therapies, Tissue homeostasis, cell regeneration, signaling pathways

@booklet{EasyChair:14415,
  author    = {Elizabeth Henry},
  title     = {Inhibition of Apoptosis and Promotion of Cell Regeneration},
  howpublished = {EasyChair Preprint 14415},
  year      = {EasyChair, 2024}}